Company:  MEDICINES CO /DE
Form Type:  SC 13G/A
Filing Date:  2/12/2020 
CIK:  0001113481 
Address:  8 SYLVAN WAY 
City, State, Zip:  PARSIPPANY, New Jersey 07054 
Telephone:  973-290-6000 
Fiscal Year:  12/31 
Description of Business
We are a biopharmaceutical company driven by our purpose to solve major medical, societal and economic challenges in healthcare. We have a singular focus on one of the greatest global healthcare challenges and burdens - that presented by atherosclerotic cardiovascular disease, or ASCVD, which remains the number one cause of death in the United States and worldwide. We take on that challenge by developing inclisiran, the investigational RNA interference, or RNAi, therapeutic, that specifically inhibits production of proprotein convertase subtilisin/kexin type 9, or PCSK9, a key protein that controls LDL-cholesterol, or LDL-C, levels. We believe inclisiran is uniquely suited to make a significant difference reducing risk in ASCVD. We have the right to develop, manufacture and commercialize inclisiran under our collaboration agreement with Alnylam Pharmaceuticals, Inc., or Alnylam.
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  FORM SC 13G/A